J Med Microbiol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Elliott, T. S.
Right arrow Articles by Greenwood, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Elliott, T. S.
Right arrow Articles by Greenwood, D.
Agricola
Right arrow Articles by Elliott, T. S.
Right arrow Articles by Greenwood, D.

The Journal of Medical Microbiology, Vol 16, Issue 3 351-362, Copyright © 1983 by Society for General Microbiology

JOURNAL ARTICLE

The response of Pseudomonas aeruginosa to azlocillin, ticarcillin and cefsulodin

T. S. Elliott and D. Greenwood

The morphological response of Pseudomonas aeruginosa to azlocillin, ticarcillin and cefsulodin was investigated by electron microscopy. Each antibiotic initially caused the formation of filaments. On further incubation in the presence of azlocillin, deposits of dense intracellular material were observed; these were absent from cells exposed to the other two antibiotics. On continued incubation, lysis of the filaments occurred, but the mode of lysis differed between the antibiotics: azlocillin caused breakage at a restricted number of sites in the cell wall, ticarcillin produced breakage at many points and cefsulodin caused extensive cell-wall damage. In addition, ticarcillin and cefsulodin appeared to cause more lysis and spheroplast formation than did azlocillin. The morphological changes correlated with turbidimetric measurements of bacterial response to the three antibiotics, which showed ticarcillin and cefsulodin to act more rapidly than azlocillin.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 1983 Society for General Microbiology.