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The Journal of Medical Microbiology, Vol 14, Issue 4 381-389, Copyright © 1981 by Society for General Microbiology

JOURNAL ARTICLE

Escherichia coli antibodies in opsonisation and protection against infection

W. C. van Dijk, H. A. Verbrugh, M. E. van Erne-van der Tol, R. Peters and J. Verhoef

The opsonic and protective capacities of rabbit antisera against Escherichia coli O, K and core-glycolipid cell-wall antigens were compared with specific antibody titres as measured by agglutination and enzyme-linked immunosorbent assay. Anti-O antisera were opsonic and protective against two noncapsulate strains. Only anti-K antisera were opsonic and protective against a K-antigen-containing strain. In a mouse model anti-core-glycolipid antiserum was not protective against challenge even by a strain bearing only core glycolipid.


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 Innate ImmunityHome page
S.E. Greisman and C.A. Johnston
Review: Evidence against the hypothesis that antibodies to the inner core of lipopolysaccharides in antisera raised by immunization with enterobacterial deep-rough mutants confer broad-spectrum protection during Gram-negative bacterial sepsis
Innate Immunity, April 1, 1997; 4(2): 123 - 153.
[Abstract] [PDF]


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