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The Journal of Medical Microbiology, Vol 13, Issue 2 345-348, Copyright © 1980 by Society for General Microbiology


JOURNAL ARTICLE

Antibiotic inhibition of protease production by Pseudomonas aeruginosa

A. M. Shibl and I. A. Al-Sowaygh

The effects of tetracycline, chloramphenicol and polymyxin B on growth and protease production by Pseudomonas aeruginosa were studied. Tetracycline inhibited protease production at concentrations much lower than those required to cause growth inhibition; the effect was not due to inhibition of protease activity by the antibiotic. In contrast, chloramphenicol and polymyxin B inhibted protease production in direct proportion to the inhibition of growth. Lysozyme-release experiments with washed tetracycline-treated cells indicated that the protease did not accumulate intracellularly. The protease-inhibiting effect of tetracycline might have therapeutic significance if it were found to occur in vivo.


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Infect. Immun.Home page
S. Herbert, P. Barry, and R. P. Novick
Subinhibitory Clindamycin Differentially Inhibits Transcription of Exoprotein Genes in Staphylococcus aureus
Infect. Immun., May 1, 2001; 69(5): 2996 - 3003.
[Abstract] [Full Text] [PDF]




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