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The Journal of Medical Microbiology, Vol 13, Issue 2 223-230, Copyright © 1980 by Society for General Microbiology

JOURNAL ARTICLE

The action of formaldehyde on staphylococcal delta haemolysin

L. E. Stearne and T. H. Birkbeck

Native staphylococcal delta haemolysin was poorly immunogenic in the mouse. After treatment with formaldehyde at pH 5 or pH 7.5, haemolytic activity was rapidly lost but antigenic reactivity retained and, at pH 5, immunogenicity was enhanced. Treatment of the haemolysin with formaldehyde at pH 9.5 reduced haemolytic activity by 97% but did not enhance immunogenicity. There was no evidence of polymerisation of formaldehyde-treated delta haemolysin, and the enhanced immunogenicity was considered to be partly due to a reduced affinity for phospholipids.




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