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The Journal of Medical Microbiology, Vol 13, Issue 1 11-17, Copyright © 1980 by Society for General Microbiology

JOURNAL ARTICLE

Crossreactivity as a factor in the immune response to Salmonella typhimurium in CBA and BALB/C mice

P. H. Wooley and A. Ebringer

The immune response to Salmonella typhimurium was investigated in CBA and BALB/C mice, by an arithmetic Widal agglutination assay. High antibody titres were obtained in CBA and low titres in BALB/C mice after secondary immunisation. A rabbit antiserum raised against S. typhimurium was tested for agglutinating activity after absorption with spleen- and lymph-node cells obtained from unimmunised CBA or BALB/C mice. BALB/C cells consistently removed more anti-S. typhimurium antibodies than did CBA cells, whilst the quantities of Fc receptor-bearing cells were found to be similar in both strains when measured by the erythrocyte-antibody rosette technique. It is suggested BALB/C mice give a low antibody response because their cell-surface antigens crossreact to a greater degree with S. typhimurium than do CBA cell-surface antigens.




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