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J Med Microbiol 11 (1978), 325-334; DOI: 10.1099/00222615-11-3-325
© 1978 Society for General Microbiology
ISSN 0022-2615
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Serial Studies of Virus Multiplication and Intestinal Damage in Gnotobiotic Piglets Infected with Rotavirus

C. F. CROUCH and G. N. WOODE

Agricultural Research Council, Institute for Research on Animal Diseases, Compton, Newbury, Berkshire RG16 0NN

Received November 22, 1977
Accepted January 30, 1978

A serial study of rotavirus infection in gnotobiotic piglets is described. They were infected when 7 days old and the course of infection was followed for 21 days, by immunofluorescence and histological examinations of the intestinal epithelium and by titration of the virus content of the gut lumen. There appeared to be two stages of recovery of the intestinal wall, the earlier stage involving non-immune mechanisms and the later involving antibody.




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