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Agricultural Research Council, Institute for Research on Animal Diseases, Compton, Newbury, Berkshire RG16 0NN
Received November 22, 1977
Accepted January 30, 1978
A serial study of rotavirus infection in gnotobiotic piglets is described. They were infected when 7 days old and the course of infection was followed for 21 days, by immunofluorescence and histological examinations of the intestinal epithelium and by titration of the virus content of the gut lumen. There appeared to be two stages of recovery of the intestinal wall, the earlier stage involving non-immune mechanisms and the later involving antibody.
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