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J Med Microbiol 11 (1978), 299-302; DOI: 10.1099/00222615-11-3-299
© 1978 Society for General Microbiology
ISSN 0022-2615
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In-Vitro Effects of Clostridium Welchii Type-D Epsilon Toxin on Guinea-Pig, Mouse, Rabbit and Sheep Cells

D. BUXTON

Department of Pathology, Moredun Research Institute, 408 Gilmerton Road, Edinburgh, EH17 7JH

Received November 30, 1977
Accepted January 16, 1978

Epsilon toxin, at relatively low concentrations, killed guinea-pig peritoneal macrophages in vitro. The cells became swollen, the nuclear and cytoplasmic membranes "blistered" and discontinuous, and the cytoplasm appeared structureless. Formalinised epsilon prototoxin was shown to bind closely to the outer surface of the cells and it is concluded that this site represents the location of the receptors for epsilon toxin.

In addition the toxin at higher concentrations killed rabbit peritoneal macrophages after increased periods of incubation, but had no demonstrable effect on other cells from guinea-pigs, rabbits, mice and sheep.




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