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Further Studies on the Mode of Action of Clostridium Welchii Type-D Epsilon Toxin

Department of Pathology, Moredum Research Institute, 408 Gilmerton Road, Edinburgh EH17 7JH

Received November 30, 1977
Accepted January 11, 1978

Intradermal injection of Clostridium welchii type-D epsilon toxin increased the permeability of blood vessels in guinea-pig skin to Evans blue dye by a mechanism not dependent on the release of histamine. The toxin was also found to raise the plasma concentration of cyclic adenosine 3', 5'-monophosphate in mice. It is concluded that epsilon toxin is an enterotoxin capable of causing widespread damage, after binding to receptor sites on the surface of certain cells, through a mechanism mediated by an adenyl cyclase-cAMP system.