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Mycoplasma Infection in Pregnant Rats: Low Viability of Foetuses and Newborn OffSpring

Y. NAOT^*, M. SHARF and A. KLEIN

^* Department of Immunology, Technion, School of Medicine, POB 9649, Haifa, Israel

Department of Obstetrics and Gynaecology, Rothschild Hospital, Haifa, Israel

Received July 27, 1977 Revision received December 1, 1977.
Accepted December 1, 1977

The controversy regarding the possible role of genital mycoplasma infection in human reproductive failure gave rise to a study in which pregnant rats, previously shown to be of normal fertility, were inoculated 7-11 days after conception with either Mycoplasma arthritidis or an equal volume of sterile broth medium. Repeated observations during the course of pregnancy revealed several pathogenic effects.

A statistically significant decrease was observed in the mean litter size of infected mothers. Furthermore, the offspring showed low viability at birth and, still more, at 10 days after birth. Our data are compatible with the hypothesis that genital mycoplasma infection plays a role in reproductive failure.