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J Med Microbiol 11 (1978), 243-248; DOI: 10.1099/00222615-11-3-243
© 1978 Society for General Microbiology
ISSN 0022-2615
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Novobiocin Resistance and Virulence of Strains of Staphylococcus Saprophyticus Isolated from Urine and Skin

F. NAMAVAR*, J. DE GRAAFF{dagger}, C. DE WITH{ddagger} and D. M. MACLAREN*

* Laboratory of Medical Microbiology, Free University, Amsterdam, The Netherlands

{dagger} Department of Oral Microbiology, Free University, Amsterdam, The Netherlands

{ddagger} Department of Medical Statistics, Free University, Amsterdam, The Netherlands

Received April 12, 1977 Revision received November 8, 1977.
Accepted November 8, 1977

A method was developed to study virulence of coagulase-negative staphy-lococci. Our results showed that coagulase-negative staphylococci injected into adult mice by the intracerebral route did not give rise to lethal infections, whereas mice aged 2 days were much more susceptible.

Novobiocin-resistant strains of Staphylococcus saprophyticus were more virulent than strains of Staphylococcus epidermidis. Strains of S. saprophyticus biotype 3 of Baird-Parker's classification varied in virulence according to novobiocin sensitivity. In the classification of Kloos and Schleifer, S. saprophyticus biotype 3 can be subdivided into four distinct staphylococcal species, namely S. saprophyticus, S. cohnii, S. haemolyticus and S. warned. S. cohnii and S. saprophyticus were equally virulent for mice aged 2 days, but novobiocin-sensitive S. haemolyticus was less virulent. On epidemiological grounds, however, it would seem that S. saprophyticus has some undefined advantage in invading the urinary tract.






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