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Urethral infection of chimpanzees by Ureaplasma urealyticum

D. TAYLOR-ROBINSON^*, R. H. PURCELL, W. T. LONDON and D. L. SLY

^* Clinical Research Centre, Watford Road, Harrow, Middlesex, USA

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA

National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland, USA

Meloy Laboratories Incorporated, Rockville, Maryland, USA

Received September 6, 1977
Accepted October 21, 1977

Two strains of Ureaplasma urealyticum serotype V that had produced urethritis in human volunteers were, after a number of subcultures in artificial media, introduced intra-urethrally into three chimpanzees. One strain given to two chimpanzees rapidly multiplied 1000-fold whereas there was less evidence that organisms of another strain multiplied in a third animal. Over a 14-day period the ureaplasmas persisted in all animals, did not spread to the throat and did not produce an inflammatory response. After this time they were eliminated by tetracycline therapy.

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