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Effects of choleragenoid and glucose on the response of dog intestine to Escherichia coli enterotoxins

D. R. NALIN^* and J. C. MCLAUGHLIN^,

^* Johns Hopkins Center for Medical Research, 550 North Broadway, Baltimore, Maryland 21505 and University of Maryland

Cholera Research Laboratory, Dacca, Bangladesh

Received March 18, 1977 Revision received November 18, 1977.
Accepted November 18, 1977

Culture supernates of Escherichia coli from diarrhoea patients were tested in dog jejunal loops for thermostable (ST) and thermolabile (LT) enterotoxins. Pre-treatment with choleragenoid blocked LT but not ST. Glucose was found to reduce fluid accumulation induced by both types of enterotoxin. The findings confirm and extend previous evidence of similarities between cholera toxin and E. coli LT and differences between it and E. coli ST.