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The Journal of Medical Microbiology, Vol 11, Issue 2 177-186, Copyright © 1978 by Society for General Microbiology

JOURNAL ARTICLE

Effects of choleragenoid and glucose on the response of dog intestine to escherichia coli enterotoxins

D. R. Nalin and J. C. McLaughlin

Culture superantes of Escherichia coli from diarrhoea patients were tested in dog jejunal loops for thermostable (ST) and thermolabile (LT) enterotoxins. Pre-treatment with choleragenoid blocked LT but not ST. Glucose was found to reduce fluid accumulation induced by both types of enterotoxin. The findings confirm and extend previous evidence of similarities between cholera toxin and E. coli LT and differences between it and E. coli ST.




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