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Effects of cephalexin, erythromycin and clindamycin on the aerobic gram-negative faecal flora in man (Plate VII)

Department of Bacteriology, The Medical School, University of Bristol, Bristol BS8 1TD

Received July 21, 1977
Accepted September 6, 1977

The effects of 5-day courses of orally administered cephalexin, clindamycin and erythromycin on the Gram-negative, aerobic faecal flora of healthy adults were examined. The concentration of cephalexin reached in the intestine was high enough to cause the emergence of resistant Gram-negative bacteria; organisms belonging to the genera Enterobacter, Citrobacter and Pseudomonas increased to easily detectable levels. The faecal concentration of erythromycin was high and caused a severe reduction of the coliform flora. Clindamycin administration resulted in a considerable increase in the coliform count; the increase in the proportion of klebsiellae was especially marked.