J Med Microbiol International Journal of Systematic and Evolutionary Microbiology
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The Journal of Medical Microbiology, Vol 11, Issue 2 125-135, Copyright © 1978 by Society for General Microbiology

JOURNAL ARTICLE

Effects of cephalexin, erythromycin and clindamycin on the aerobic Gram-negative faecal flora in man

C. L. Hartley, H. M. Clements and K. B. Linton

The effects of 5-day courses of orally administered cephalexin, clindamycin and erythromycin on the Gram-negative, aerobic faecal flora of healthy adults were examined. The concentration of cephalexin reached in the intestine was high enough to cause the emergence of resistant Gram-negative bacteria; organisms belonging to the genera Enterobacter, Citrobacter and Pseudomonas increased to easily detectable levels. The faecal concentration of erythromycin was high and caused a severe reduction of the coliform flora. Clindamycin administration resulted in a considerable increase in the coliform count; the increase in the proportion of klebsiellae was especially marked.




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