J Med Microbiol International Journal of Systematic and Evolutionary Microbiology
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The Journal of Medical Microbiology, Vol 11, Issue 1 7-14, Copyright © 1978 by Society for General Microbiology


JOURNAL ARTICLE

The ability of smooth and rough strains of Streptococcus pneumoniae to activate human complement by the alternative pathway

M. Edwards and J. M. Stark

Three capsulate pneumococcal strains of serotypes 1, 2 ans 3, and one non-capsulate strain of serotype 47, were found to activate human complement by the alternative pathway to a similar extent over the concentration range examined. Nevertheless, the capsulate strains, in contrast to the non-capsulate, are known to require complement attachment for phagocytosis and it is therefore postulated that the toxic by-products released cause the wave of oedema characteristic of pneumococcal lobar pneumonia.





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