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The Journal of Medical Microbiology, Vol 10, Issue 4 479-482, Copyright © 1977 by Society for General Microbiology

JOURNAL ARTICLE

Treatment of experimental Escherichia coli infection in mice with colicine V

H. W. Smith and M. B. Huggins

Concentrated non-toxic preparations of colicine V were obtained by filtering centrifugates of soft-agar cultures of a Col V+ K12 strain of E. coli through Millipore filters in which the colicine V was retained. These preparations, given subcutaneously, favourably influenced the course of disease in mice infected intraperitoneally with a pathogenic strain of E. coli that was very sensitive to colicine V in vitro. A beneficial effect was noted even when treatment was delayed until the mice were visibly ill.


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P. Barrow, M. Lovell, and A. Berchieri Jr.

Clin. Vaccine Immunol., May 1, 1998; 5(3): 294 - 298.
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