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The Journal of Medical Microbiology, Vol 10, Issue 1 43-48, Copyright © 1977 by Society for General Microbiology

JOURNAL ARTICLE

Small virus particles in faeces of patients with infectious hepatitis (hepatitis A)

S. J. Skidmore and E. H. Boxall

Forty-one faecal samples from infectious-hepatitis patients and their contacts were investigated for the presence of hepatitis-A-associated viral particles. Of these, 16 gave a positive result by immune electronmicroscopy or caesium-chloride density-gradient centrifugation. The latter method proved invaluable in detecting small numbers of virus particles. The particles found had buoyant density of 1-34-1-35 and a size range of 21-28 nm. Epidemiological evidence suggested that they might be the causative agent of hepatitis A.




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