J Med Microbiol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Miler, J. M.
Right arrow Articles by Lowbury, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miler, J. M.
Right arrow Articles by Lowbury, E. J.
Agricola
Right arrow Articles by Miler, J. M.
Right arrow Articles by Lowbury, E. J.

The Journal of Medical Microbiology, Vol 10, Issue 1 19-27, Copyright © 1977 by Society for General Microbiology

JOURNAL ARTICLE

A new polyvalent Pseudomonas vaccine

J. M. Miler, J. F. Spilsbury, R. J. Jones, E. A. Roe and E. J. Lowbury

This paper describes the preparation, chemical characterisation and immunogenic properties of a new polyvalent pseudomonas vaccine. New cultural methods were devised which allowed a build-up of the immunogen in the cell wall of the bacteria, and mild extraction techniques were used to remove the immunogens from the cell wall of living bacteria without apparent physical or chemical change which might affect immunogenicity. The polyvalent vaccine comprised 16 component vaccines, each a lipid-protein-carbohydrate complex extracted from one of the 16 different serotypes of Pseudomonas aeruginosa. Single injections into mice of each of the 16 component vaccines induced protection against several strains of homologous serotypes within 3 days of vaccination. The polyvalent vaccine induced similar protection against several strains of each of the 16 serotypes. We would like to thank R. E. Dyster, K. Digby and J. Simmonds for their technical assistance.


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
E. Mansouri, J. Gabelsberger, B. Knapp, E. Hundt, U. Lenz, K.-D. Hungerer, H. E. Gilleland Jr., J. Staczek, H. Domdey, and B.-U. von Specht
Safety and Immunogenicity of a Pseudomonas aeruginosa Hybrid Outer Membrane Protein F-I Vaccine in Human Volunteers
Infect. Immun., March 1, 1999; 67(3): 1461 - 1470.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL J MED MICROBIOL MICROBIOLOGY J GEN VIROL ALL SGM JOURNALS
Copyright © 1977 Society for General Microbiology.